Pentylenetetrazole-induced Seizure Susceptibility in the Tau58/4 Transgenic Mouse Model of Tauopathy
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چکیده
منابع مشابه
Protective effect of ginger against the pentylenetetrazole-induced seizure threshold model in streptozocin treated-diabetic mice
Introduction: There is evidence that diabetes affects seizure susceptibility. Ginger (Zingiber officinale Roscoe) which is used in traditional medicine has antioxidant activity and neuroprotective effects. The aim of this study was to evaluate the seizure threshold induced by pentylenetetrazole (PTZ) in diabetic mice after induction of diabetes with streptozocin and to examine the possible ...
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Quinine, is an anti-malarial drug that specifically blocks connexin 36 (Cx36) at gap junction channels. Quinine has suppressed ictal epileptiform activity in vitro without decreasing neuronal excitability. Thus, we considered the possible anticonvulsant effects of quinine in the pentylenetetrazole (PTZ) model of seizure. Moreover, we studied the hypnotic effect and locomotor activity of quinine...
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Background and Objectives: Epilepsy is a neurodevelopmental disorder, which based on the evidences of prenatal factors, has a significant influence on the development of nervous system in offspring. The present study was performed to investigate the effect of seizure in pregnancy on pentylenetetrazol (PTZ)-induced seizure behavior in offspring. Methods: In this experimental study, after preg...
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Background: Epilepsy as a neurological disorder is characterized by unpredictable and periodic seizure. In the present study the anticonvulsant effect of different doses of salep hydroalcoholic extract on pentylenetetrazole (PTZ) induced seizures was investigated. Materials and Methods: The animal model of seizure was established by the intraperitoneal injection of pentylenetetrazole (PTZ- 85...
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ژورنال
عنوان ژورنال: Neuroscience
سال: 2020
ISSN: 0306-4522
DOI: 10.1016/j.neuroscience.2019.11.007